Pathsure lists 44 rest areas in South Carolina. All 44 are open 24 hours a day. Between them they cover 32 ZIP codes across the South Carolina area. Listings include Rest Area - Orangeburg, SC, Rest Area - Orangeburg, SC and Interstate 26 East Rest Area.
- Rest Area - Orangeburg, SC
142 Eastrest Lane, Orangeburg, SC, 29115 · Open 24/7
- Rest Area - Orangeburg, SC
140 Westrest Lane, Orangeburg, SC, 29115 · Open 24/7
- Interstate 26 East Rest Area
123 I-26 E Rest Area Lane, Gaston, SC, 29053 · Open 24/7
- Interstate 26 West Rest Area
123 Interstate 26 Lane West, Gaston, SC, 29053 · Open 24/7
- Rest Area - Sayreville, SC
9495 Interstate 26, Sayreville, SC, 0 · Open 24/7
- South Carolina Welcome Center
89 Interstate 77, Fort Mill, SC, 29708 · Open 24/7
- Rest Area - Richburg, SC
3120 Gaston Farm Road, Richburg, SC, 29729 · Open 24/7
- Rest Area - Richburg, SC
3173 Crenshaw Parkway, Richburg, SC, 29729 · Open 24/7
- South Carolina Welcome Center - Hardeeville
4968 Jasper Highway, Hardeeville, SC, 29927 · Open 24/7
- Rest Area - Yemassee, SC
46528 Interstate 95 South, Yemassee, SC, 29945 · Open 24/7
- Rest Area - St. George, SC
74 Interstate 95 North, St. George, SC, 29477 · Open 24/7
- Rest Area - Yemassee, SC
46529 Interstate 95 North, Yemassee, SC, 29945 · Open 24/7
- South Carolina Welcome Center
100 Welcome Center Place, Fair Play, SC, 29643 · Open 24/7
- Rest Area - Santee, SC
180 Southrest Lane, Santee, SC, 29142 · Open 24/7
- South Carolina Welcome Center
2121 17th Highway 17, Little River, SC, 29566 · Open 24/7
- Service Area - Fort Mill, SC
1400 A O Jones Boulevard, Fort Mill, SC, 29715 · Open 24/7
- Service Area - Leesville, SC
2658 Ben Franklin Road, Leesville, SC, 29070 · Open 24/7
- Rest Area - South Lynchburg, SC
2655 Interstate 95, South Lynchburg, SC, 29080 · Open 24/7
- Service Area - Enoree, SC
3883 Cross Anchor Road, Enoree, SC, 29335 · Open 24/7
- Service Area - Inman, SC
1940 Highway 292, Inman, SC, 29349 · Open 24/7
- Service Area - Graniteville, SC
7015 Midnight Pass, Graniteville, SC, 29829 · Open 24/7
- Rest Area - Anderson, SC
1750 I-85 Northbound, Anderson, SC, 29625 · Open 24/7
- Rest Area - Anderson, SC
2331 I-85 Southbound, Anderson, SC, 29621 · Open 24/7
- Rest Area - North Augusta, SC
48 Interstate 20, North Augusta, SC, 29841 · Open 24/7
- Service Area - Graniteville, SC
651 Bettis Academy Road, Graniteville, SC, 29829 · Open 24/7
- Service Area - Batesburg-Leesville, SC
1694 Old 96 Indian Trail, Batesburg-Leesville, SC, 29006 · Open 24/7
- Rest Area - Bonds Crossroads, SC
64 A East Interstate 26, Bonds Crossroads, SC, 29355 · Open 24/7
- Rest Area - Lugoff, SC
946 Interstate 20, Lugoff, SC, 29078 · Open 24/7
- Rest Area - Lugoff, SC
945 Interstate 20, Lugoff, SC, 29078 · Open 24/7
- Service Area - Walterboro, SC
11089 Augusta Highway, Walterboro, SC, 29488 · Open 24/7
- Service Area - Fair Play, SC
274 Herring Road, Fair Play, SC, 29643 · Open 24/7
- Scotchman Travel Plaza
2454 Mt Holly Road, Rock Hill, SC, 29730 · Open 24/7
- Service Area - Winnsboro, SC
11193 State Highway 200, Winnsboro, SC, 29180 · Open 24/7
- Service Area - North Augusta, SC
115 Laurel Lake Drive, North Augusta, SC, 29860 · Open 24/7
- Service Area - Roebuck, SC
6200 Highway 221, Roebuck, SC, 29376 · Open 24/7
- Service Area - Dillon, SC
1203 Radford Boulevard, Dillon, SC, 29536 · Open 24/7
- Service Area - Aynor, SC
2949 US 501, Aynor, SC, 29511 · Open 24/7
- Rest Area - Laurens, SC
6305 I 385, Laurens, SC, 29360 · Open 24/7
- Rest Area - Santee, SC
138 Northrest Lane, Santee, SC, 29142 · Open 24/7
- Rest Area - South Lynchburg, SC
2650 Interstate 95, South Lynchburg, SC, 29080 · Open 24/7
- Rest Area - Kinards, SC
64 REST AREA West Interstate 26, Kinards, SC, 29355 · Open 24/7
- Service Area - South of the Border, SC
3346 Bldg Highway 301 North, South of the Border, SC, 29547 · Open 24/7
- Service Area - Inman, SC
9580 Asheville Highway, Inman, SC, 29349 · Open 24/7
- Service Area - Laurens, SC
21420 Highway 221 North, Laurens, SC, 29360 · Open 24/7